From San Francisco International Airport (SFO)
- Start out going east on Airport Access Road. (0.1 mile)
- Take a slight left toward US-101/I-380/I-280. (0.1 mile)
- Take a slight left onto Airport Access Road. (0.2 mile)
- Merge onto US-101 N/Bayshore Freeway N toward San Francisco. (2.3 mile)
- Take the S Airport Boulevard exit, EXIT 424. (0.2 mile)
- Turn right onto S Airport Boulevard. (0.2 miles)
- Best Western Plus Grosvenor SFO, at 380 S Airport Boulevard, South San Francisco, CA, is on the right.
From San Jose or the Peninsula
- Take Highway 101 North to San Francisco.
- Take South Airport Boulevard exit and turn right.
- The hotel is located on the right-hand side of the street.
From Oakland Bay Bridge & San Francisco
- Take Highway 101 South to San Jose and take the South Airport Boulevard exit.
- Stay in far-right lane and turn right at the stop sign.
- Go under the overpass/freeway and proceed up to the signal. At the signal, turn right onto South Airport Boulevard.
- Go past two traffic lights and our hotel will be on the right-hand side of the street.